Passenger mutations finder
Me-PaMuFind-It
The Me-PuMaFind-It web tool allows scientists to easily get a list of potential passenger mutations present in any 129-derived transgenic mouse. To start a search with the 'Me-PaMuFind-It' tool, the user simply has to enter a gene symbol and choose the number of backcrosses. Next, the user will be given information that can be subdivided in four main parts:
- general information about the entered gene
- list of genes containing 129-derived protein coding variants that affect the entered gene
- list of genes containing 129-derived UTR and upstream variants that affect the entered gene
- list of genes that are affected by the entered gene in case it contains one or more 129-derived protein coding variants
This web tool is based on sequences that were released by The Wellcome Trust Sanger Institute (Keane et al., 2011), version 3. The predictions made are indicative and should still be verified experimentally.
Tom.VandenBerghe@irc.vib-ugent.be and Peter.Vandenabeele@irc.vib-ugent.be for
Paco.Hulpiau@irc.vib-ugent.be and Liesbet.Martens@irc.vib-ugent.be for
Citation: Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice